Background and Context
Research considering the impact of sex and gender on symptoms in inflammatory bowel disease (IBD) has been limited.
New Findings
Transgender and gender-diverse individuals with IBD report high abdominal pain and depression levels. Fatigue was the core symptom for cisgender women and anxiety was the core symptom for cisgender men.
Limitations
The sample was recruited online and the majority of participants had active disease as measured by validated instruments.
Clinical Research Relevance
Fatigue and anxiety may serve as important intervention targets for those with IBD. Future studies should evaluate the impact of sex and/or gender differences.
Basic Research Relevance
The underlying mechanisms regarding symptoms of fatigue and anxiety remain to be explored within the IBD population.
